Tim Lekic Selected Research

Collagenases (Collagenase)

6/2015	Protease-activated receptor 1 and 4 signal inhibition reduces preterm neonatal hemorrhagic brain injury.
5/2013	Hydrogen inhalation ameliorated mast cell-mediated brain injury after intracerebral hemorrhage in mice.
2/2013	Evaluation of the hematoma consequences, neurobehavioral profiles, and histopathology in a rat model of pontine hemorrhage.
9/2012	Modeling intracerebral hemorrhage in mice: injection of autologous blood or bacterial collagenase.
7/2012	Rodent neonatal germinal matrix hemorrhage mimics the human brain injury, neurological consequences, and post-hemorrhagic hydrocephalus.
1/2011	NC1900, an arginine vasopressin analogue, fails to reduce brain edema and improve neurobehavioral deficits in an intracerebral hemorrhagic stroke mice model.
1/2011	Characterization of the brain injury, neurobehavioral profiles, and histopathology in a rat model of cerebellar hemorrhage.
1/2011	The postpartum period of pregnancy worsens brain injury and functional outcome after cerebellar hemorrhage in rats.
1/2011	Hydrogen inhalation is neuroprotective and improves functional outcomes in mice after intracerebral hemorrhage.
3/2009	Effect of gap junction inhibition on intracerebral hemorrhage-induced brain injury in mice.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Tim Lekic Research Topics

Disease

25	Brain Injuries (Brain Injury) 11/2017 - 01/2008
19	Brain Edema (Cerebral Edema) 11/2017 - 01/2008
15	Hemorrhage 01/2017 - 01/2011
13	Cerebral Hemorrhage 01/2017 - 03/2009
9	Stroke (Strokes) 01/2018 - 05/2009
8	Hypoxia (Hypoxemia) 01/2016 - 05/2009
7	Atrophy 01/2017 - 03/2010
5	Edema (Dropsy) 11/2017 - 01/2008
5	Ischemia 10/2011 - 05/2009
4	Ischemic Stroke 01/2018 - 05/2009
4	Infarction (Infarctions) 01/2016 - 05/2009
3	Hydrocephalus (Hydrocephaly) 09/2017 - 07/2012
3	Hematoma 03/2016 - 01/2011
3	Intellectual Disability (Idiocy) 01/2011 - 01/2011
3	Cerebral Palsy (Spastic Diplegia) 01/2011 - 01/2011
2	Neuroinflammatory Diseases 01/2017 - 04/2013
2	Memory Disorders (Memory Loss) 01/2017 - 12/2011
2	Intracranial Hemorrhages (Intracranial Hemorrhage) 01/2016 - 01/2016
2	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 01/2015 - 12/2011
2	Brain Ischemia (Cerebral Ischemia) 04/2014 - 07/2010
2	Body Weight (Weight, Body) 04/2013 - 02/2010
2	Inflammation (Inflammations) 03/2013 - 07/2012
2	Rupture 02/2013 - 01/2011
2	Hemorrhagic Stroke 01/2011 - 03/2010
1	Multiple Sclerosis 01/2017
1	Iron Overload 01/2016
1	Exsanguination 01/2016
1	Neurologic Manifestations (Neurological Manifestations) 05/2013
1	Cerebral Infarction 04/2013
1	Periventricular Leukomalacia (Neonatal Cerebral Leukomalacia) 07/2012
1	Gliosis 07/2012
1	Ataxia (Dyssynergia) 01/2011
1	Cardiomegaly (Heart Hypertrophy) 01/2011

Drug/Important Bio-Agent (IBA)

10	Collagenases (Collagenase)FDA Link 06/2015 - 03/2009
4	Free RadicalsIBA 01/2016 - 03/2010
4	Oxygen (Dioxygen)IBA 01/2016 - 02/2010
4	Neuroprotective AgentsIBA 04/2012 - 03/2009
4	MelatoninIBA 01/2011 - 01/2008
3	Fingolimod Hydrochloride (FTY720)FDA Link 01/2017 - 01/2011
3	salicylhydroxamic acid (SHAM)IBA 01/2016 - 03/2009
3	TOR Serine-Threonine KinasesIBA 01/2016 - 07/2012
3	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2016 - 02/2010
3	HydrogenIBA 05/2013 - 01/2011
3	Arginine Vasopressin (Argipressin)IBA 03/2011 - 01/2011
3	AntioxidantsIBA 01/2011 - 01/2008
2	VenomsIBA 11/2017 - 01/2017
2	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 01/2017 - 03/2012
2	Sphingosine-1-Phosphate ReceptorsIBA 01/2017 - 12/2013
2	Small Interfering RNA (siRNA)IBA 03/2016 - 04/2013
2	Coloring Agents (Dyes)IBA 01/2016 - 01/2016
2	Evans Blue (Blue, Evans)FDA Link 01/2016 - 01/2016
2	OsteopontinIBA 01/2016 - 01/2016
2	Hemoglobins (Hemoglobin)IBA 01/2016 - 07/2012
2	Thrombin FDA Link 06/2015 - 07/2012
2	N- (2- cyclohexyloxy- 4- nitrophenyl)methanesulfonamideIBA 06/2015 - 02/2010
2	VitronectinIBA 03/2014 - 07/2012
2	Isoflurane FDA LinkGeneric 12/2013 - 07/2010
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 02/2011 - 07/2010
1	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 11/2017
1	Clopidogrel (Plavix)FDA Link 11/2017
1	Dabigatran FDA Link 09/2017
1	Fibrinogen (Factor I)FDA Link 01/2017
1	N- (1- azabicyclo(2.2.2)oct- 3- yl)furo(2,3- c)pyridine- 5- carboxamideIBA 01/2017
1	2-chloro-5-nitrobenzanilideIBA 03/2016
1	Scavenger Receptors (Scavenger Receptor)IBA 03/2016
1	Insulin-Like Growth Factor I (IGF-1)IBA 01/2016
1	PAR-1 ReceptorIBA 06/2015
1	Sirolimus (Rapamycin)FDA Link 06/2015
1	Proteinase-Activated ReceptorsIBA 06/2015
1	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 01/2015
1	Imatinib Mesylate (Gleevec)FDA Link 01/2015
1	Deferoxamine (Desferal)FDA LinkGeneric 08/2014
1	Tissue Plasminogen Activator (Alteplase)FDA Link 04/2014
1	Transforming Growth Factors (Transforming Growth Factor)IBA 03/2014
1	Extracellular Matrix ProteinsIBA 03/2014
1	Glial Fibrillary Acidic ProteinIBA 03/2014
1	sphingosine kinaseIBA 12/2013
1	Tryptases (Tryptase)IBA 05/2013
1	Phosphotransferases (Kinase)IBA 05/2013
1	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 04/2013
1	3-nitrotyrosineIBA 07/2012
1	CateninsIBA 04/2012
1	Y 27632IBA 04/2012
1	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 04/2012
1	Minocycline (Cyclops)FDA LinkGeneric 12/2011
1	Matrix Metalloproteinase 1 (Interstitial Collagenase)IBA 10/2011
1	Glucose (Dextrose)FDA LinkGeneric 10/2011
1	Erythropoietin FDA Link 10/2011
1	Tissue Inhibitor of Metalloproteinase-1IBA 10/2011
1	Opioid Receptors (Opioid Receptor)IBA 02/2011
1	WortmanninIBA 02/2011
1	Morphine (MS Contin)FDA LinkGeneric 02/2011
1	Naloxone (Narcan)FDA LinkGeneric 02/2011
1	geldanamycinIBA 01/2011

Therapy/Procedure

10	Therapeutics 11/2017 - 01/2008
6	Ligation 01/2016 - 05/2009
2	Neurosurgical Procedures 11/2017 - 01/2008
1	Thrombolytic Therapy 01/2018
1	Splenectomy 04/2013
1	Ischemic Postconditioning 02/2011